BAX anticorps (N-Term)

N° du produit ABIN2787858

Cet anticorps Lapin Polyclonal détecte spécifiquement BAX dans WB. Il présente une réactivité envers Humain, Souris, Rat, Porc, Boeuf (Vache), Lapin, Chien, Mouton, Cheval et Cobaye.

Aperçu rapide pour BAX anticorps (N-Term) (ABIN2787858)

Antigène: BAX (BCL2-Associated X Protein (BAX))

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Lapin, Chien, Mouton, Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAX est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-BAX anticorps

Épitope: N-Term

Séquence: IMKTGALLLQ GFIQDRAGRM GGEAPELALD PVPQDASTKK LSECLKRIGD

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 91%, Rat: 100%, Sheep: 100%

Attributs du produit: This is a rabbit polyclonal antibody against BAX. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human BAX

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 218 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur BAX

Antigène: BAX (BCL2-Associated X Protein (BAX))

Autre désignation: BAX

Sujet: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Alias Symbols: BCL2L4
Protein Interaction Partner: CYCS, ZBTB24, UBC, CASP9, CASP8, CASP7, CASP3, BCL2L1, BCL2, CLU, MDM2, MCL1, BAX, BAG3, YWHAB, VCP, CRYAB, CRYAA, BAK1, XIAP, TP53, KCNA3, HSPA4, XRCC6, XRCC5, HDAC6, BAD, PSMC5, PSMC3, PARK7, UHRF2, RNF144B, OYE2, TOMM22, TOMM40, MEPCE, MOAP1, BBC3, PPP
Protein Size: 218

Poids moléculaire: 24 kDa

ID gène: 581

NCBI Accession: NM_004324, NP_004315

UniProt: Q07812

Pathways: Signalisation p53, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response